BioViotica

Chaetoglobosin F

Name: Chaetoglobosin F
Brand: BioViotica
SKU: BVT-0461
Price: 215.00 CHF
Availability: InStock

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BVT-0461-M0011 mgCHF 215.00

Specifications / Handling

More Information
Product Details
Synonyms	(21,22-Dihydro,19-ketone,20β-alcohol)-chaetoglobosin A
Product Type	Chemical
Properties
Formula	C₃₂H₃₈N₂O₅
MW	530.7
CAS	55945-75-0
Source/Host Chemicals	Isolated from Chaetomium sp.
Purity Chemicals	≥98% (HPLC, NMR)
Appearance	Off-white solid.
Solubility	Soluble in DMSO, acetone or dichloromethane. Poorly soluble in methanol. Insoluble in water.
Identity	Determined by ¹H-NMR and MS.
Declaration	Manufactured by BioViotica.
InChi Key	KTFGDHPTDQFFRL-WSLWJRNMSA-N
Smiles	[H][C@]12[C@H](CC3=CNC4=CC=CC=C34)NC(=O)[C@]11C(=O)CC[C@@H](O)C(=O)\C(C)=C/[C@@H](C)C\C=C\[C@@]1([H])[C@@H]1O[C@]1(C)[C@H]2C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Cytochalasan mycotoxin, derivative of chaetoglobosin A (Prod. No. BVT-0092).
Phytotoxic.
Cytotoxic against HCT116 (human colon cancer cells).
Antibacterial (Ps. aeruginosa).
Anti-inflammatory and immunomodulatory compound.

Product-specific References

Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13]cytochalasans from Chaetomium spp. I. Production, isolation, and some cytological effects of chaetoglobosin A-J: S. Sekita, et al.; Chem. Pharm. Bull. 30, 1609 (1982)
Chaetoglobosins, cytotoxic 10-(indol-3yl)-[13]cytochalasans from Chaetomium spp. III. Structures of chaetoglobosins C, E, F, G, and J: S. Sekita, et al.; Chem. Pharm. Bull. 30, 1629 (1982)
Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019: G. Ding, et al.; J. Nat. Prod. 69, 302 (2006)
Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01: S. Thohinung, et al.; Arch. Pharm. Res. 33, 1135 (2010)
Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum: J. Zhang, et al.; Planta Med. 76, 1910 (2010)
New azaphilones from Chaetomium globosum isolated from the built environment: D.R. McMullin, et al.; Tetrahedron Lett. 54, 568 (2013)
Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway: C. Hua, et al.; Immunobiology 218, 292 (2013)
Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment: D.R. Mcmullin, et al.; Mycotoxin Res. 29, 47 (2013)
Production of an antimicrobial cytochalasan by an endophytic Chaetomium globosum HYML55 from Hypericum mysorense and its RNA secondary structure analysis: P. Samaga, et al.; Chem. Ecology 30, 566 (2014)
Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities: H. Li, et al.; J. Agr. Food Chem. 62, 3734 (2014)

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