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Chaetoglobosin A

BVT-0092-M001 1 mg $65.00
BVT-0092-M005 5 mg $220.00
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Additional Information

Product Data
Synonyms NSC366739; BRN1097707
Properties
Formula C32H36N2O5
MW 528.7
CAS 50335-03-0
Source/Host Chemicals Isolated from Chaetomium sp.
Purity ≥98% (HPLC)
Appearance Yellow to orange solid.
Solubility Soluble in methanol; almost insoluble in water.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key OUMWCYMRLMEZJH-HSXMBTRQSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic.
  • Cytochalasan analog with anti-fungal activity.
  • Phytotoxic, nematicidal and anti-bacterial activity.
  • Exhibits cytotoxic effects against human cancer cell lines.
  • Induces apoptosis in lymphocytic leukemia cells by targeting the cytoskeleton.
  • Enhances fibrinolytic activity of bovine aortic endothelial cells.
  • Mycotoxin.

Product References

  1. Acute toxic effects of chaetoglobosin A, a new cytochalasan compound produced by Chaetomium globosum, on mice and rats: K. Ohtsubo, et al.; Jpn. J. Exp. Med. 48, 105 (1978)
  2. Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13]cytochalasans from Chaetomium spp. I. Production, isolation and some cytological effects of chaetoglobosins A-J: S. Sekita, et al.; Chem. Pharm. Bull. 30, 1609 (1982)
  3. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B: C. Shinohara, et al.; J. Antibiot. 53, 262 (2000)
  4. Phytotoxic chaetoglobosins are produced by the plant pathogen Calonectriam organii (anamorph Cylindrocladium scoparium): C. Von Wallbrunn, et al.; J. Gen. Appl. Microbiol. 47, 33 (2001)
  5. Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum: W. Jiao, et al.; J. Nat. Prod. 67, 1722 (2004)
  6. Growth and mycotoxin production by Chaetomium globosum: M.R. Fogle, et al.; Mycopathologia 164, 49 (2007)
  7. New azaphilones from Chaetomium globosum isolated from the built environment: D. R. McMullin, et al.; Tetrahedron Lett. 54, 568 (2013)
  8. Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis: K. Ishiuchi, et al.; JACS 135, 7371 (2013)
  9. Nematicidal activity of chaetoglobosin A produced by Chaetomium globosum NK102 against Meloidogyne incognita: Y. Hu, et al.; J. Agricult. Food Chem. 61, 41 (2013)
  10. Efficacy assessment of antifungal metabolites from Chaetomium globosum No.05, a new biocontrol agent, against Setosphaeria turcica: G. Zhang, et al.; BioControl 64, 90 (2013)
  11. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton: P. B. Knudson, et al.; Leukemia 28, 1289 (2014)
  12. Production of vineomycin A1 and chaetoglobosin A by Streptomyces sp. PAL114: A. Aouiche, et al.; Ann. Microbiol. 65, 1351 (2015)
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