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IDO1 (human) Enzyme+Inhibitor Set

AG-44B-0006-KI01 1 Set INQ
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Additional Information

Product Data
Synonyms Indoleamine 2,3-dioxygenase; INDO; IDO
Properties
Crossreactivity Human
Kit Contains 1 Set
1x50µg of IDO1 (human) (rec.) (His) (highly active) (Prod. No. AG-40B-0161)
1x100µg of MMG-0358 (Prod. No. AG-CR1-3630)

Download our online Assay Procedure/Protocol.
Product Type Kit
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Documents
Assay Procedure Download Document Download
MSDS Download Document Download
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Product Description

IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity.

The IDO1 (human) Enzyme+Inhibitor Set contains the active enzyme IDO1 (human) (rec.) (His) (AG-40B-0161), compound MMG-0358 (AG-CR1-3630), a very potent and specific inhibitor of IDO1, and protocols that can be used for IDO1 enzyme activity and IDO1 inhibition experiments.

Both components can be used in vitro:

•  For cell culture to study the effect of hIDO1 in a cellular system.
•  For screening assay to search for new inhibitors of hIDO1.
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