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MMG-0358

AG-CR1-3630-M001 1 mg INQ
AG-CR1-3630-M005 5 mg INQ
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Additional Information

Product Data
Synonyms 4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol
Properties
Formula C8H6ClN3O
MW 195.6
CAS 1378976-02-3
Purity ≥98% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO (20mM).
Identity Determined by NMR.
Other Product Data NOTE: Prepare a 20mM solution in pure anhydrous DMSO. Prior to performing biological experiments we recommend to make dilutions of the stock solution into aqueous buffers (1mM solution of MMG-0358 in a 95% buffer/5% DMSO mixture).
InChi Key NBDFMTBYKCBTSW-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Description

  • Potent triazole IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor.
  • Has IC50 values of 2nM in a cellular assay on mIDO1, 80nM in a cellular assay on hIDO1, 330nM in an enzymatic assay on hIDO1 at pH 6.5 and 71nM in an enzymatic assay on hIDO1 at pH 7.4. Shown to be active in vivo.

Product References

  1. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. 55, 5270 (2012)
  2. Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors: U.F. Roehrig, et al.; J. Med. Chem. 58, 9421 (2015) (Review)
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