Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
IGFL3 (human) (rec.)
420
CHF
CHF 420.00
In stock
AG-40B-0090-C01010 µgCHF 420.00
AG-40B-0090-30103 x 10 µgCHF 840.00
Figure 1: IGFL3 (human) (rec.) (Prod. No. AG-40B-0090) binds to its receptor IGFLR1 (human): Fc (human) (Prod. No. AG-40B-0087).
Method: IGFLR1 (human): Fc was coated on an ELISA plate at 1μg/ml overnight at room temperature. IGFL3 (human) (rec.) or negative control was added (starting at 8μg/ml with a twofold serial dilution) for one hour and then detected using an anti-FLAG® antibody (HRP).
Method: IGFLR1 (human): Fc was coated on an ELISA plate at 1μg/ml overnight at room temperature. IGFL3 (human) (rec.) or negative control was added (starting at 8μg/ml with a twofold serial dilution) for one hour and then detected using an anti-FLAG® antibody (HRP).
| Product Details | |
|---|---|
| Synonyms | Insulin Growth Factor-like Family Member 3 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
Human IGFL3 (aa 25-125) is fused at the N-terminus to a FLAG®-tag. |
| Crossreactivity | Human |
| Specificity |
Binds to human IGFLR1 (Prod. No. AG-40B-0087). |
| MW | ~15-17kDa (SDS-PAGE); ~100kDa (Hexamer) by SEC |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.5EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
UniProt link Q6UXB1: IGFL3 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
Product References
- Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1: A.A. Lobito, et al.; J. Biol. Chem. 286, 18969 (2011)
Related Products
