Additional Information
| Product Data | |
|---|---|
| Synonyms | Insulin Growth Factor-like Family Member 3 |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence | Human IGFL3 (aa 25-125) is fused at the N-terminus to a FLAG®-tag. |
| Crossreactivity | Human |
| Specificity | Binds to human IGFLR1 (Prod. No. AG-40B-0087). |
| MW | ~12kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.5EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data | UniProt link Q6UXB1: IGFL3 (human) |
| Product Type | Protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -20°C. |
| Documents | |
| MSDS |
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Product Description
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
Product References
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IGFL3 (human) (Prod. No. AG-40B-0090) binds to its receptor IGFLR1 (human):Fc (human) (Prod. No. AG-40B-0087). Method: IGFLR1 (human):Fc was coated on an ELISA plate at 1μg/ml overnight at room temperature. IGFL-3 (human) or a negative control, Omentin (human) (Prod. No. AG-40B-0042), were added (starting at 8μg/ml with a twofold serial dilution) during one hour and then detected using an anti-FLAG® antibody (HRP).
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