AdipoGen Life Sciences

IGFLR1 (human):Fc (human) (rec.)

CHF 470.00
In stock
AG-40B-0087-C05050 µgCHF 470.00
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Product Details
Synonyms IGF-like Family Receptor 1; Transmembrane Protein 149; TMEM149; U2 Small Nuclear RNA Auxiliary Factor 1-like 4
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

Human IGFLR1 (aa 23-154) is fused at the C-terminus to the Fc portion of human IgG1.

Crossreactivity Human
Specificity

Binds to its ligand IGFL1 (human) (Prod. No. AG-40B-0244) or IGFL3 (human) (Prod. No. AG-40B-0090) in the subnanomolar range (< 1ng/ml).

MW ~50kDa (SDS-PAGE)
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.05EU/μg purified protein (LAL test; Lonza).
Concentration 1mg/ml after reconstitution.
Reconstitution Reconstitute with 50μl sterile water.
Formulation Lyophilized. Contains PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.)

Other Product Data

UniProt link Q9H665: IGFLR1 (human)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description

Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

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