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SynKinase
AZ9482
CHF 0.00
In stock
SYN-3046-M0011 mgCHF 128.00
SYN-3046-M0055 mgCHF 270.00
SYN-3046-M01010 mgCHF 412.00
SYN-3046-M05050 mgCHF 1'263.00
SYN-3046-M100100 mgINQ
| Product Details | |
|---|---|
| Synonyms | 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
| Product Type | Chemical |
| Properties | |
| Formula | C26H22N6O2 |
| MW | 450.5 |
| CAS | 1825345-33-2 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data | Target: PARP | Kinase Group: N/A | Substrate: N/A |
| InChi Key | ZDDPBFWHZOJFHF-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1).
Product References
- Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering: J.W. Johannes, et al.; Bioorg. Med. Chem. Lett. 25, 5743 (2015)
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