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SynKinase
H-1152
114
CHF
CHF 114.00
In stock
SYN-1221-M0011 mgCHF 114.00
SYN-1221-M0055 mgCHF 270.00
SYN-1221-M01010 mgCHF 412.00
SYN-1221-M100100 mgINQ
SYN-1221-M05050 mgINQ
| Product Details | |
|---|---|
| Synonyms | (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride; H1152 |
| Product Type | Chemical |
| Properties | |
| Formula | C16H21N3O2S . 2HCl |
| MW | 319.4 . 72.9 |
| CAS | 871543-07-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: ROCK | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | BFOPDSJOLUQULZ-GXKRWWSZSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling, smooth muscle contraction and neuronal development.
Product References
- The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway: Y. Sasaki, et al.; Pharmacol. Ther. 93, 225 (2002)
- Development of specific Rho-kinase inhibitors and their clinical application: M. Tamura, et al.; Biochim. Biophys. Acta 1754, 245 (2005)
- Proerectile effects of the rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis: C.E. Teixeira, et al.; J. Pharmacol. Exp. Ther. 315, 155 (2005)
- H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse: H.L. Wang, et al.; Neuropharmacol. 70, 1 (2013)
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