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SynKinase
NVP-BSK805 dihydrochloride
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SYN-1136-M0011 mgCHF 234.00
SYN-1136-M0055 mgCHF 355.00
SYN-1136-M01010 mgCHF 497.00
SYN-1136-M05050 mgCHF 1’348.00
SYN-1136-M100100 mgINQ
Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | NVPBSK805 |
| Product Type | Chemical |
| Properties | |
| Formula | C27H28F2N6O . 2HCl |
| MW | 490.6 . 72.9 |
| CAS | 1092499-93-8 (free base) |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: JAK2 | Kinase Group: PTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | NUOCAPALWRHKCU-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
NVP-BSK805 is a potent and selective quinoxaline JAK2 inhibitor with IC(50) values of 0.48, 0.56 and 0.58nM for JAK2 JH1, FL JAK (V617F) and FL JAK2 wt, respectively.
Product-specific References
- Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805: F. Baffert, et al.; Mol. Cancer Ther. 9, 1945 (2010)
- Effects of Jak2 Type 1 Inhibitors NVP-BSK805 and NVP-BVB808 on Jak2 Mutation-Positive and Bcr-Abl-Positive Cell Lines: F. Ringel, et al.; Acta Haematol. 132, 75 (2014)
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