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SynKinase
JNJ-38877605
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Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | JNJ38877605 |
| Product Type | Chemical |
| Properties | |
| Formula | C19H13F2N7 |
| MW | 377.4 |
| CAS | 943540-75-8 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: c-MET | Kinase Group: RTK | Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | JRWCBEOAFGHNNU-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Scientific Background Information
Product Description
JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).
Product-specific References
- MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors: V. Cepero, et al.; Cancer Res. 70, 7580 (2010)
- Targeting c-Met in melanoma: Mechanism of resistance and efficacy of novel combinatorial inhibitor therapy: D. Etnyre, et al.; Cancer Biol. Ther. 15, 1129 (2014)
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