Additional Information
| Product Data | |
|---|---|
| Synonyms | Interleukin-2; Aldesleukin |
| Properties | |
| Source/Host | E. coli |
| Sequence | Rat IL-2 (aa 21-155) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Rat |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <1EU/μg protein (LAL test; Lonza). |
| Reconstitution | Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS (pH 7.4). |
| Other Product Data | NCBI reference NP_446288.1: IL-2 rat) |
| Origin | Manufactured by Chimerigen. |
| Product Type | Protein |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Product Description
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-γ and TNF-α and -β. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
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