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IL-2 (rat) (rec.) (His)

CHI-RR-30002-C010 10 µg $150.00
CHI-RR-30002-C050 50 µg $450.00
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Additional Information

Product Data
Synonyms Interleukin-2; Aldesleukin
Properties
Source/Host E. coli
Sequence Rat IL-2 (aa 21-155) is fused at the C-terminus to a His-tag.
Crossreactivity Rat
Purity ≥95% (SDS-PAGE)
Endotoxin Content <1EU/μg protein (LAL test; Lonza).
Reconstitution Reconstituted in sterile H2O not less than 100μg/ml, which can then be further diluted in other aqueous solutions.
Formulation Lyophilized from 0.2μm-filtered solution in PBS (pH 7.4).
Other Product Data NCBI reference NP_446288.1: IL-2 rat)
Origin Manufactured by Chimerigen.
Product Type Protein
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Product Description

Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-γ and TNF-α and -β. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
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