Chemodex

Thiocolchicoside

Name: Thiocolchicoside
Brand: Chemodex
SKU: CDX-T0175
Price: 651.00 CHF
Availability: InStock

As low as CHF 217.00

In stock

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CDX-T0175-M02525 mgCHF 217.00

CDX-T0175-M100100 mgCHF 651.00

Specifications / Handling

More Information
Product Details
Synonyms	BRN0072205; NSC147755; Coltramyl; 10-thio-Colchicoside; 2-Demethoxy-2-glucosidoxythiocolchicine
Product Type	Chemical
Properties
Formula	C₂₇H₃₃NO₁₀S
MW	563.6
CAS	602-41-5
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	Light yellow to dark yellow powder.
Solubility	Soluble in water (10 mg/ml).
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	LEQAKWQJCITZNK-AXHKHJLKSA-N
Smiles	COC1=C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C2CC[C@H](NC(C)=O)C3=CC(=O)C(SC)=CC=C3C2=C1OC
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Described to be a muscle relaxant. Anti-inflammatory agent with analgesic properties. Shown to be an anticancer compound through inhibition of NF-κB and NF-κB-regulated gene products. Therapeutic option for the management of bone metastatic disease.

Product-specific References

(1) J.M. Janbroers; Acta Ther. 13, 221 (1987) | (2) M. Carta, et al.; Neuropharmacology 51, 805 (2006) | (3) S. Reuter, et al.; Cancer Prev. Res. 3, 1462 (2010) | (4) O. Micheau, et al.; Br. J. Pharmacol. 165, 2124 (2012)

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