Chemodex

TFMU

Name: TFMU
Brand: Chemodex
SKU: CDX-T0003
Price: 95.00 CHF
Availability: InStock

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CDX-T0003-G0011 gCHF 95.00

CDX-T0003-GG252.5 gCHF 189.00

Specifications / Handling

More Information
Product Details
Synonyms	4-(Trifluoromethyl)umbelliferone
Product Type	Chemical
Properties
Formula	C₁₀H₅F₃O₃
MW	230.14
CAS	575-03-1
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (NMR)
Appearance	White to off-white crystalline powder.
Solubility	Soluble in alcohols, DMSO or DMF.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	CCKWMCUOHJAVOL-UHFFFAOYSA-N
Smiles	OC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

Product-specific References

(1) P. Baranczewski; Assay and Drug Developm. Techn. 2(4), 345 (2004) | (2) A.B. Renwick; Xenobiotica 30(10), 955 (2000) | (3) G. Luyten et al.; J. Histochem. Cytochem. 33, 965 (1985)

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