Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
Chemodex
Sildenafil citrate
135
CHF
CHF 135.00
In stock
CDX-S0078-M05050 mgCHF 135.00
CDX-S0078-M250250 mgCHF 543.00
| Product Details | |
|---|---|
| Synonyms | 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt; Actra-Rx; Edegra; Viagra; Tonafil; Apodefil; UK 92480 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H30N6O4S . C6H8O7 |
| MW | 474.6 . 192.1 |
| CAS | 171599-83-0 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO (20mg/ml). |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | DEIYFTQMQPDXOT-UHFFFAOYSA-N |
| Smiles | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCC1=NN(C)C2=C1N=C(NC2=O)C1=CC(=CC=C1OCC)S(=O)(=O)N1CCN(C)CC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice |
Keep cool and dry. Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6nM (3nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s = 0.26 and 65μM, respectively). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-dependent protein kinase. While most notable for its use in the treatment of erectile dysfunction, sildenafil’s vasorelaxant properties have also been used to control vascular tone in pulmonary arterial hypertension and high-altitude pulmonary edema associated with altitude sickness. The citrate salt has superior water solubility and pharmacokinetics compared to the base salt of sildenafil.
Product References
(1) N.K. Terrett, et al.; Bioorg. Med. Chem. Lett. 6, 1819 (1996) | (2) J. Richalet, et al.; Am. J. Respir. Crit. Care Med. 171, 275 (2005) | (3) C.E. Teixeira, et al.; J. Pharmacol. Exp. Ther. 316, 654 (2006) | (4) S. Jung, et al.; Arch. Pharm. Res. 34, 451 (2011)