Parecoxib

Specifications / Handling

More Information
Product Details
Synonyms	N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide; Dynastat; SC-69124
Product Type	Chemical
Properties
Formula	C₁₉H₁₈N₂O₄S
MW	370.4
CAS	198470-84-7
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	White powder.
Solubility	Soluble in water.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	TZRHLKRLEZJVIJ-UHFFFAOYSA-N
Smiles	O=C(CC)NS(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Potent and selective COX-2 inhibitor. Water-soluble amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib. Has anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib.

Product References

(1) J.J. Talley, et al.; J. Med. Chem. 43, 1661 (2000) | (2) S.S. Padi, et al.; Eur. J. Pharmacol. 491, 69 (2004) | (3) A.B. Reksidler, et al.; Eur. J. Pharmacol. 560, 163 (2007) | (4) A. Abbate, et al.; J. Cardiovasc. Pharmacol. 49, 416 (2007) | (5) H. Schroeder, et al.; Neurochem. Int. 58, 9 (2011) | (6) Z. Ye, et al.; Neurochem. Res. 37, 321 (2012) | (7) S.J.Chong, et al.; Int. J. Inflam. 2014, 972645 (2014)

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