Chemodex

13-cis-4-Oxoretinoic acid

Name: 13-cis-4-Oxoretinoic acid
Brand: Chemodex
SKU: CDX-O0048
Price: 150.00 CHF
Availability: InStock

As low as CHF 150.00

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CDX-O0048-M0011 mgCHF 150.00

CDX-O0048-M0055 mgCHF 597.00

CDX-O0048-M02525 mgCHF 2’388.00

Specifications / Handling

More Information
Product Details
Synonyms	4-Oxoisotretinoin; Ro 22-6595
Product Type	Chemical
Properties
Formula	C₂₀H₂₆O₃
MW	314.42
CAS	71748-58-8
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	Dark yellow powder.
Solubility	Soluble in acetone, chloroform, ethanol (slightly) or ether.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	GGCUJPCCTQNTJF-FAOQNJJDSA-N
Smiles	C\C(\C=C\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C\C(O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Mayor active metabolites of 13-cis-retinoic acid (important drug in dermatology and treatment of neuroblastoma) with effects on gene transcription that regulate growth, differentiation and inflammation in normal and neoplastic skin cells. Shown to be as active as 13-cis-retinoic acid against neuroblastoma cell lines. Can be used as reference compound.

Product-specific References

(1) F.M. Vane & C.J. Bugge; Drug Metab. Dispos. 9, 515 (1981) | (2) J.M. Baron, et al.; J. Invest. Derm. 125, 143 (2005) | (3) S.E. Rowbotham, et al.; DMD 38, 1211 (2010) | (4) P. Sonawane, et al.; Br. J. Pharmacol. 171, 5330 (2014)

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