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GSH-OEt

CDX-G0006-M100 100 mg INQ
CDX-G0006-M500 500 mg INQ
CDX-G0006-G005 5 g INQ
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Additional Information

Product Data
Synonyms Glutathione reduced ethyl ester
Properties
Formula C12H21N3O6S
MW 335.38
CAS 92614-59-0
Source/Host Synthetic.
Purity ≥95% (HPLC)
Appearance Solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Origin Manufactured by Chemodex.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key JKRODHBGNBKZLE-YUMQZZPRSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.

Product Description

GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.

Product References

(1) M. A. Retamal et al.; PNAS, 103(12), 4475 (2006) | (2) C. Leeuwenburgh et al.; J. Nutr., 128(12), 2420 (1998) | (3) K.Nishida et al.; Res. Commun. Chem. Pathol. Pharmacol. 82, 49 (1993)
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