Chemodex

3,5-Dimethyl-NAPQI

Name: 3,5-Dimethyl-NAPQI
Brand: Chemodex
SKU: CDX-A0163
Price: 258.00 CHF
Availability: InStock

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CDX-A0163-M01010 mgCHF 258.00

CDX-A0163-M02525 mgCHF 516.00

Specifications / Handling

More Information
Product Details
Synonyms	NA-3,5-Bqi; N-Acetyl-3,5-dimethyl-4-benzoquinone imine
Product Type	Chemical
Properties
Formula	C₁₀H₁₁NO₂
MW	177.2
CAS	74827-85-3
Source/Host Chemicals	Synthetic
Purity Chemicals	≥95.0% (HPLC)
Appearance	Orange powder.
Solubility	Soluble in chloroform.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	VUPORYDINWWWKZ-UHFFFAOYSA-N
Smiles	CC(=O)N=C1C=C(C)C(=O)C(C)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Metabolite. Oxidizing analog of N-acetyl-p-benzoquinone imine (NAPQI), a toxic metabolite of acetaminophen (paracetamol). Primarily oxidizes protein thiols. Shows cytotoxic properties, through disruption of intracellular Ca2+ homeostasis. Compound can be used as analytical reference material.

Product-specific References

(1) R. van de Straat, et al.; Biochem. Pharmacol. 36, 2065 (1987) | (2) L. Rossi, et al.; Mol. Pharmacol. 34, 674 (1988) | (3) P. Nicotera, et al.; Chem. Res. Toxicol. 2, 46 (1989) | (4) P. Nicotera, et al.; Arch. Biochem. Biophys. 283, 200 (1990)

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