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Violacein

BVT-0473-M001 1 mg INQ
BVT-0473-M005 5 mg INQ
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Additional Information

Product Data
Synonyms Anorosin
Properties
Formula C20H13N3O3
MW 343.3
CAS 548-54-9
Source/Host Isolated from Chromobacterium violaceum.
Purity ≥97% (HPLC, NMR)
Appearance Dark purple to black solid.
Solubility Soluble in DMSO. Partially soluble in methanol. Insoluble in water and usual organic solvents.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key XAPNKXIRQFHCHN-QGOAFFKASA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibacterial, antifungal and antiprotozoal agent.
  • Quorum sensing metabolite.
  • Antitumor compound.
  • Protective against UV-C irradiation.
  • Possesses immunomodulatory, analgesic and antipyretic activity.
  • Antiulcerogenic and antiviral agent.
  • Indole-derived purple-colored pigment (free of deoxyviolacein).

Product References

  1. The synthesis of violacein and related compounds: J.A. Ballantine, et al.; J. Chem. Soc. [London] 1960, 2292 (1960)
  2. Evaluation of the antiulcerogenic activity of violacein and its modulation by the inclusion complexation with beta-cyclodextrin: N. Duran, et al.; Can. J. Physiol. Pharmacol. 81, 387 (2003)
  3. Cytotoxicity and potential antiviral evaluation of violacein produced by Chromobacterium violaceum: C.R. Andrighetti-Froehner, et al.; Mem. Inst. Oswaldo Cruz. 98, 843 (2003)
  4. Violacein: properties and biological activities: N. Duran, et al.; Biotechn. Appl. Biochem. 48, 127 (2007)
  5. Potential applications of violacein: a microbial pigment: M. Duran, et al.; Med. Chem. Res. 21, 1524 (2012)
  6. The protective effects of the violacein pigment against UV-C irradiation in Chromobacterium violaceum: A.N. Abboud & A. Arment; Ohio J. Sci. 111, 28 (2013)
  7. Violacein: properties and production of a versatile bacterial pigment: S.Y. Choi, et al.; Biomed Res. Int. 2015, 1 (2015)
  8. Violacein treatment modulates acute and chronic inflammation through the suppression of cytokine production and induction of regulatory T cells: L. Verinaud, et al.; PLoS One 10, e0125409 (2015)
  9. Violacein induces cell death by triggering mitochondrial membrane hyperpolarization in vitro: A.M. Leal, et al.; Microbiol. 15, 1 (2015)
  10. Synergistic combination of violacein and azoles that leads to enhanced killing of major human pathogenic dermatophytic fungi Trichophyton rubrum: S. Anju, et al.; Front. Cell. Infect. Microbiol. 2015, 557 (2015)
  11. Antifungal activity of violacein purified from a novel strain of Chromobacterium sp. NIIST (MTCC 5522): A. Sasidharan, et al.; J. Microbiol. [Seoul] 53, 694 (2015)
  12. Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo: L. Masuelli, et al.; Tumor Biol. 37, 3705 (2016)
  13. Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2: A.A. Alshatwi, et al.; Exp. Toxicol. Pathol. 68, 89 (2016)
  14. Complete genome sequence of antibiotic and anticancer agent violacein producing Massilia sp. strain NR 4-1: N.R. Myeong, et al.; J. Biotechnol. 223, 36 (2016)
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