BioViotica

Pyridomycin

Name: Pyridomycin
Brand: BioViotica
SKU: BVT-0455
Price: 325.00 CHF
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BVT-0455-M0011 mgCHF 325.00

Specifications / Handling

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Product Details
Synonyms	Antibiotic U 24544; Erizomycin; NSC 246134
Product Type	Chemical
Properties
Formula	C₂₇H₃₂N₄O₈
MW	540.6
CAS	18791-21-4
Source/Host Chemicals	Isolated from Streptomyces sp.
Purity Chemicals	≥98% (1H-NMR, HPLC)
Appearance	Off-white solid.
Solubility	Soluble in DMSO, methanol, water, dichloromethane or acetone.
Identity	Determined by ¹H-NMR and MS.
Declaration	Manufactured by BioViotica.
InChi Key	WHIKSLGSXKIHCA-IGCCMALHSA-N
Smiles	CC\C(C)=C1/OC(=O)[C@H](C)[C@H](O)[C@H](CC2=CC=CN=C2)NC(=O)[C@@H](NC(=O)C2=C(O)C=CC=N2)[C@@H](C)OC1=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light when in solution.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Cyclodepsipeptide antibiotic. Unusual 12-membered macrocyclic depsipeptide comprises three unique subunits incorporating two substituted pyridines.
Potent antitubercular agent.
Inhibitor of NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis.
Shown to be active against isoniazid-resistant mycobacteria.

Product-specific References

A new antibiotic, pyridomycin: K. Maeda, et al.; J. Antibiot. (Tokyo) 6, 140 (1953)
Structure of pyridomycin: G. Koyama, et al.; Tetrahedron Lett. 37, 3587 (1967)
Chemistry of pyridomycin: H. Ogawara, et al.; Chem. Pharm. Bull. 16, 679 (1968)
Synthetic studies of pyridomycin. V. Total synthesis of pyridomycin: M. Kinoshita, et al.; Tetrahedron Lett. 30, 7419 (1989)
Identification and characterization of the pyridomycin biosynthetic gene cluster of streptomyces pyridomyceticus NRRL B-2517: T. Huang, et al.; J. Biol. Chem. 286, 20648 (2011)
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid: R. C. Hartkoorn, et al.; EMBO Mol. Medicine 4, 1032 (2012)
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA: R. C. Hartkoorn, et al.; Nat. Chem. Biol. 10, 96 (2014)

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