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3-Deoxyaphidicolin

BVT-0451-C250 250 µg $70.00
BVT-0451-M001 1 mg $210.00
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Additional Information

Product Data
Synonyms (+)-3-Deoxyaphidicolin
Properties
Formula C20H34O3
MW 322.5
CAS 85483-00-7
Source/Host Chemicals Isolated from Phoma sp. BS 7210.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water.
Identity Determined by 1H-NMR and MS.
Origin Manufactured by BioViotica.
InChi Key VHWTVINEPPOCLA-DTMQFJJTSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
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Product Description

  • Inhibitor of eukaryotic DNA synthesis.
  • Mycotoxin.
  • Phytotoxic and cytotoxic agent.
  • Specific inhibitor of DNA polymerase α.

Product References

  1. Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase α, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
  2. 3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984)
  3. Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985)
  4. An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985)
  5. Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase α in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987)
  6. Structure-activity relationships for the inhibition of DNA polymerase α by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989)
  7. Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)
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