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BioViotica
3-Deoxyaphidicolin
85
CHF
CHF 85.00
In stock
BVT-0451-C250250 µgCHF 85.00
BVT-0451-M0011 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | (+)-3-Deoxyaphidicolin |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H34O3 |
| MW | 322.5 |
| CAS | 85483-00-7 |
| Source/Host Chemicals | Isolated from Phoma sp. BS 7210. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | VHWTVINEPPOCLA-DTMQFJJTSA-N |
| Smiles | [H][C@]12C[C@@H]3C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CCC[C@@](C)(CO)[C@]1([H])CC2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability | Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Inhibitor of eukaryotic DNA synthesis.
- Mycotoxin.
- Phytotoxic and cytotoxic agent.
- Specific inhibitor of DNA polymerase α.
Product References
- Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase α, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
- 3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984)
- Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985)
- An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985)
- Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase α in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987)
- Structure-activity relationships for the inhibition of DNA polymerase α by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989)
- Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)
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