BioViotica

3-Deoxyaphidicolin

Name: 3-Deoxyaphidicolin
Brand: BioViotica
SKU: BVT-0451
Price: 250.00 CHF
Availability: InStock

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BVT-0451-C250250 µgCHF 85.00

BVT-0451-M0011 mgCHF 250.00

Specifications / Handling

More Information
Product Details
Synonyms	(+)-3-Deoxyaphidicolin
Product Type	Chemical
Properties
Formula	C₂₀H₃₄O₃
MW	322.5
CAS	85483-00-7
Source/Host Chemicals	Isolated from Phoma sp. BS 7210.
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water.
Identity	Determined by ¹H-NMR and MS.
Declaration	Manufactured by BioViotica.
InChi Key	VHWTVINEPPOCLA-DTMQFJJTSA-N
Smiles	[H][C@]12C[C@@H]3C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CCC[C@@](C)(CO)[C@]1([H])CC2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light when in solution.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Product-specific References

Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase α, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984)
Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985)
An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985)
Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase α in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987)
Structure-activity relationships for the inhibition of DNA polymerase α by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989)
Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)

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