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Cytochalasin H

BVT-0447-M001 1 mg INQ
BVT-0447-M005 5 mg INQ
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Additional Information

Product Data
Synonyms Paspalin P1; Kodocytochalasin 1; Cytochalasin O; NSC305222; 17-Deoxo-21-acetylzygosporin D
Properties
Formula C30H39NO5
MW 493.6
CAS 53760-19-3
RTECS HA5306000
Source/Host Isolated from Phomopsis sp.
Purity ≥98% (HPLC, NMR)
Appearance White solid.
Solubility Soluble in DMSO, methanol or acetone.
Identity Determined by 1H-NMR and 13C-NMR.
Origin Manufactured by BioViotica.
InChi Key NAEWXXDGBKTIMN-CGCBHLOZSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution protect from light at -20°C.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Description

  • Potent mycotoxin.
  • Phytotoxin.
  • Actin polymerization inhibitor. Used in actin polymerization and cytoskeletal reorganization studies.
  • Antibacterial, antifungal, nematocidal and antitumor compound.
  • Apoptosis inducer.
  • Anti-angiogenic agent.
  • Shows immunosuppressive activity.
  • Shown to modulate the CNS with potential anti-parkinson activity.

Product References

  1. Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.: J.M. Wells, et al.; Can. J. Microbiol. 22, 1137 (1976)
  2. Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1: M. A. Beno, et al.; JACS 99, 4123 (1977)
  3. Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells: S. Ghaskadbi & L. Mulherkar; Indian J. Exp. Biol. 20, 869 (1982)
  4. Effects of cytochalasin H on chick embryo explants cultured in vitro: S. Ghaskadbi, et al. Toxicology 33, 323 (1984)
  5. Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell Biol. 105, 1473 (1987)
  6. A new immunosuppressive cytochalasin isolated from a Pestalotia sp.: N. S. Burres, et al.; J. Antibiot. 45, 1367 (1992)
  7. Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganization, on platelet function: P. Natajaran, et al.; Platelets, 11, 467 (2000)
  8. 1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08): Y. Tao, et al.; Magn. Reson. Chem. 46, 501 (2008)
  9. Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa: S. Xu, et al.; Chem. Biodivers. 6, 739 (2009)
  10. Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines: S.M. Stoeger & K.H. Cowan; Cancer Chemother. Pharmacol. 63, 807 (2009)
  11. Application of cytochalasin compound cytochalasin H in manufacture of the medicine for resisting Parkinson's disease: L. Shet, et al.; CN103816149 A20140528 (2014) (Patent)
  12. Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis Thorns: J. Lee, et al.; Biol. Pharm. Bull. 37, 6 (2014)
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