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Piperafizine B

BVT-0446-C500 500 µg $110.00
BVT-0446-M001 1 mg $180.00
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Product Data
Synonyms 3,6-Dibenzylidene-2,5-piperazinedione; 3,6-Dibenzylidene-2,5-dioxopiperazine; 3,6-Bis(phenylmethylene)-2,5-piperazinedione
Formula C18H14N2O2
MW 290.3
CAS 74720-33-5
Source/Host Chemicals Isolated from Streptomyces thioluteus.
Purity ≥98% (HPLC)
Appearance Light yellow solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR and 13C-NMR.
Origin Manufactured by BioViotica.
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
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Product Description

  • Diketopiperazine derivative. Analog of Piperafizine A.
  • Potentiator of vincristine cytotoxicity.

Product References

  1. The production of 3-benzylidene-6-isobutylidene-2,5-dioxopiperazine, 3,6-dibenzylidene-2,5-dioxopiperazine,3-benzyl-6-benzylidene-2,5-dioxopiperazine, and 3,6-dibenzyl-2,5-dioxopiperazine by a variant of Streptomyces noursei: R. Brown, et al.; J. Org. Chem. 30, 277 (1960)
  2. α,β-unsaturated carboxylic acid derivatives. Part 18. Syntheses of geometric isomers of 3,6-dibenzylidene and 3-p-anisylidene-6-benzylidene-2,5-piperazinedions: C. Shin, et al.; J. Chem. Soc. Perkin Trans. 1, 419 (1980)
  3. Molecular and electronic structure of the dehydroalanine derivatives: the cyclicdipeptide of dehydrophenylalanine: D. Ajo, et al.; Tetrahedron 41, 5543 (1985)
  4. Piperafizines A and B, potentiators of cytotoxicity of vincristine: H. Kamei, et al.; J. Antibiot. 43, 1018 (1990)
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