BioViotica

Rugulosin

Name: Rugulosin
Brand: BioViotica
SKU: BVT-0444
Price: 395.00 CHF
Availability: InStock

As low as CHF 110.00

In stock

Only %1 left

BVT-0444-M0011 mgCHF 110.00

BVT-0444-M0055 mgCHF 395.00

Specifications / Handling

More Information
Product Details
Synonyms	(+)-Rugulosin; NSC 160880; NSC 249990; Radicalisin
Product Type	Chemical
Properties
Formula	C₃₀H₂₂O₁₀
MW	542.5
CAS	23537-16-8
RTECS	VM1610000
Source/Host Chemicals	Isolated from Penicillium sp.
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow solid.
Solubility	Soluble in DMSO, acetone, ethanol or methanol.
Identity	Determined by ¹H-NMR, MS and optical rotation.
Declaration	Manufactured by BioViotica.
InChi Key	QFDPVUTXKUGISP-UHFFFAOYSA-N
Smiles	CC1=CC2=C(C(O)=C1)C(=O)C1=C(O)[C@H]3C(O)C4C5C(O)[C@H](C(O)=C6C(=O)C7=C(O)C=C(C)C=C7C(=O)C356)C14C2=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light when in solution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Mycotoxin.
Antibiotic (Streptococcus, Corynebacterium, MRSA).
Antiviral, HIV-1 integrase inhibitor.
DNA replication, transcription and repair inhibitor (carcinogenic activity).
RNA polymerase and ribonuclease H inhibitor.
Insecticidal activity.
Inhibitor of N-Hsp90.

Product-specific References

Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)
Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)
Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)
Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)
Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)
Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)
Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)
New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)
Inhibition and binding of Rugulosin with N-Hsp90: J.-J.Chen, et al.; Gaodeng Xuexiao Huaxue Xuebao 32, 88 (2011)
Antibiotically active metabolites from Talaromyces wortmannii, an endophyte of Aloe vera: R. Bara, et al.; J. Antibiot. 66, 491 (2013)
Distribution of the foliar fungal endophyte Phialocephala scopiformis and its toxin in the crown of a mature white spruce tree as revealed by chemical and qPCR analyses: S. L. Frasz, et al.; Can. J. Forest Res. 44,1138 (2014)
Comparison of cytotoxic extracts from fruiting bodies, infected insects and cultured mycelia of Cordyceps formosana: R.-L. Lu, et al.; Food Chem. 145, 1066 (2014)

Call	+41 61 926 6040
Fax	+41 61 926 6049