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Trypacidin

BVT-0442-M001 1 mg INQ
BVT-0442-M005 5 mg INQ
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Additional Information

Properties
Formula C18H16O7
MW 344.3
CAS 1900-29-4
RTECS WG9780000
Source/Host Isolated from Aspergillus fumigatus.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, acetone or dichloromethane.
Identity Determined by 1H-NMR, MS and optical rotation.
Origin Manufactured by BioViotica.
InChi Key KMZYINVXZDQCKC-GOSISDBHSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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Product Description

  • Antibiotic.
  • Antibacterial and antiprotozoal (trypanocidal).
  • Toxic to human A549 lung cells.
  • Necrosis inducer.
  • Toxic to human bronchial epithelial cells.
  • Stimulating the growth of corn seedling roots.
  • Inhibits IL-6 secretion, collagen IV and fibronectin production

Product References

  1. Antiprotozoal antibiotics. II. Isolation and characterization of trypacidin, a new antibiotic, active against Trypanosoma cruzi and Toxoplasma gondii: J. Balan, et al.; J. Antibiot. 16, 157 (1963)
  2. Trypacidin a new protozoal antibiotic: J. Balan, et al.;  Naturwissenschaften 5, 227 (1964)
  3. The structure of Trypacidin: J. Balan, et al.; Acta Chem. Scand. 19, 528 (1965)
  4. Growth of Trypanosoma cruzi in human heart tissue cells and effects of aminonucleoside of puromycin, trypacidin and aminopterin: W.E. Gutteridge, et al.; J. Protozool. 16, 521 (1969)
  5. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells: T. Gauthier, et al.; PLoS One 7, e29906 (2012)
  6. Chemical constituents of Aspergillus sp EJC08 isolated as endophyte from Bauhinia guianensis and their antimicrobial activity: E. Pinheiro, et al.; An. Acad. Bras. Cienc. 85, 1247 (2013)
  7. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy: Y. Yang, et al.; Bioorg. Med. Chem. Let. 23, 3905 (2013)
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