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5-Methylmellein

BVT-0413-M001 1 mg $70.00
BVT-0413-M005 5 mg $280.00
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Additional Information

Product Data
Synonyms 5- Methylochracin; 3,4-Dihydro-8-hydroxy-3,5-dimethyl-1H-2-benzopyran1- one; 3,4-Dihydro-8-hydroxy-3,5-dimethylisocoumarin
Properties
Formula C11H12O3
MW 192.2
CAS 7734-92-1
Source/Host Chemicals Isolated from Fusicoccum amygdalis.
Purity ≥98% (HPLC)
Appearance Pale yellow powder.
Solubility Soluble in DMSO, chloroform or dichloromethane.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key YETSBBYQOFXYGV-SSDOTTSWSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Widespread fungal pentaketide.
  • Weak antibacterial, antifungal and antiviral activity.
  • Specific inhibitor of human DNA polymerase λ.
  • Weak antigerminative activity.

Product References

  1. 5-Methylmellein, a new natural dihydroisocoumarin: A. Ballio, et al.; Tetrahedron Lett. 1966, 3723 (1966)
  2. (-)-5-Methylmellein and catechol derivatives from four semecarpus species: R.C. Carpenter, et al.; Phytochemistry 19, 445 (1980)
  3. 3-Methyl-3,4-dihydroisocoumarins and related compounds from the ascomycete family xylariaceae: J.R. Anderson & R.L. Edwards; J. Chem. Soc. Perkin Trans I 1983, 2185 (1983)
  4. Dihydroisocoumarins from fungi: isolation, structure elucidation, circular dichroism and biological activity: K. Krohn, et al.; Phytochemistry 45, 313 (1997)
  5. Nodulisporol and nodulisporone, novel specific inhibitors of human DNA polymerase λ from a fungus, Nodulisporium sp.: S. Kamisuki, et al.; Bioorg. Med. Chem. 15, 3109 (2007)
  6. Bioactive aromatic derivatives from endophytic fungus, Cytospora sp.: S. Lu, et al.; Nat. Prod. Commun. 6, 661 (2011)
  7. Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity: S. Amand, et al.; J. Nat. Prod. 75, 798 (2012)
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