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Pikromycin

BVT-0400-M001 1 mg $80.00
BVT-0400-M005 5 mg $240.00
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Additional Information

Product Data
Synonyms Picromycin; Amaromycin; Antibiotic B 62169A; Albomycetin
Properties
Formula C28H47NO8
MW 525.7
CAS 19721-56-3
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥95% (HPLC)
Appearance White crystalline solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key UZQBOFAUUTZOQE-AKYJXTIJSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic. 14-Membered macrolide.
  • Active against Gram-positive bacteria including mycobacteria.
  • Prolyl endopeptidase (PREP) inhibitor.

Product References

  1. Pikromycin, ein neues Antibiotikum aus Actinomyceten: H. Brockmann & W. Henkel; Naturwissenschaften 37, 138 (1950)
  2. Pikromycin, ein bitter schmeckendes antibioticum aus Actinomyceten: H. Brockmann & W. Henkel; Chem. Ber. 84, 284 (1951)
  3. The crystal and molecular structure of Pikromycin: A. Furusaki, et al.; Bull. Chem. Soc. Jpn. 55, 59 (1982)
  4. Albocycline- and carbomycin-type macrolides, inhibitors of human prylol endopeptidases: C. Christner, et al.; J. Antibiot. 51, 368 (1998)
  5. The Methymycin/pikromycin pathway: A model for metabolic diversity in natural product biosynthesis: J. D. Kittendorf & D. H. Sherman; Bioorg. Med. Chem. 17, 2137 (2009)
  6. Total synthesis of Pikromycin: H.-S. Oh & H.-Y. Kang; J. Org. Chem. 77, 1125 (2012) 
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