BioViotica

Zearalenone

Name: Zearalenone
Brand: BioViotica
SKU: BVT-0394
Price: 75.00 CHF
Availability: InStock

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BVT-0394-M0055 mgCHF 75.00

BVT-0394-M02525 mgCHF 240.00

Specifications / Handling

More Information
Product Details
Synonyms	Toxin F2; BRN 1350216; FES; NCI-C50226; Zenone
Product Type	Chemical
Properties
Formula	C₁₈H₂₂O₅
MW	318.4
Merck Index	13: 10169
CAS	17924-92-4
Source/Host Chemicals	Isolated from Fusarium graminearum.
Purity Chemicals	≥98% (HPLC)
Appearance	Off-white solid.
Solubility	Soluble in DMSO, methanol or acetone.
Identity	Determined by ¹H-NMR and UV.
Declaration	Manufactured by BioViotica.
InChi Key	MBMQEIFVQACCCH-QBODLPLBSA-N
Smiles	C[C@H]1CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C2C(=O)O1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Resorcylic acid lactone.
Mycotoxin.
Regulator of fungal morphogenesis.
Mycoestrogen with anabolic and uterotrophic activity.
Ecdysteroid antagonist.
Gonadotropin inhibitor.
Interleukin antagonist.
Apoptosis inducer.
Analytical standard in food industry.

Product-specific References

The structure of zearalenone: W. H. Urry, et al.; Tetrahedron Lett. 1966, 3109 (1966)
Physicochemical data for some selected mycotoxins: A E. Pohland, et al.; Pure Appl. Chem. 54, 2219 (1982)
Zearalenone: K. Panneerselvam, et al.; Acta Cryst. C52, 3095 (1996)
The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor: X. Ding, et al.; Toxicol. Sci. 91, 448 (2006)
Trace mycotoxin analysis in complex biological and food matrices by liquid chromatography-atmospheric pressure ionisation mass spectrometry: P. Zollner & B. Mayer-Helm; J. Chromatogr. A 1136, 123 (2006)
The PKS4 gene of Fusarium graminearum is essential for zearalenone production: E. Lysoe, et al; Appl. Environ. Microbiol. 72, 3924 (2006)
Chemistry and biology of resorcyclic acid lactones: N. Winssinger & S. Barluenga; Chem. Commun. 2007, 22 (2007)
Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin: A. Zinedine, et al.; Food Chem. Toxicol. 45, 1 (2007)
Biomimetic synthesis of resorcylate natural products utilizing late stage aromatization: concise total syntheses of the marine antifungal agents 15G256ι and 15G256β: I. Navarro, et al.; JACS 130, 10293 (2008)
Effects of exposure to zearalenone on porcine oocytes and sperm during maturation and fertilization in vitro: R. Sambuu, et al.; J. Reprod. Dev. 57, 547 (2011)
Fusarium graminearum mycotoxins and their biosynthetic genes: H. Son & Y.-W. Lee; Mycotoxins 62, 29 (2012)
Zearalenone induces apoptosis and necrosis in porcine granulose cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway: L. Zhu, et al.; J. Cell. Physiol. 227, 1814 (2012)

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