BioViotica

Aureothricin

Name: Aureothricin
Brand: BioViotica
SKU: BVT-0345
Price: 110.00 CHF
Availability: InStock

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BVT-0345-C500500 µgCHF 50.00

BVT-0345-M0011 mgCHF 110.00

Specifications / Handling

More Information
Product Details
Synonyms	Propionylpyrrothione; Farcinicin; N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)propionamide
Product Type	Chemical
Properties
Formula	C₉H₁₀N₂O₂S₂
MW	242.3
CAS	574-95-8
Source/Host Chemicals	Isolated from Streptomyces thioluteus.
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow powder.
Solubility	Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	UGZYFXMSMFMTSM-UHFFFAOYSA-N
Smiles	CCC(=O)NC1=C2SSC=C2N(C)C1=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Antibiotic.
Active against Gram-positive and Gram-negative bacteria, yeast, filamentous fungi, protozoa and insects.
Potent bacterial and yeast RNA polymerases inhibitor.
Inhibitor of fungal mannan and glucan formation.
Similar to thiolutin.
Antitumor compound.

Product-specific References

The structures of thiolutin and aureothricin, antibiotics containing a unique pyrrolinonodithiole nucleus: W. D. Celmer & I. A. Solomons; J. Am. Chem. Soc. 77, 2861 (1955)
Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
Thiolutin, an inhibitor of huvec adhesion to vitronectin, reduces paxillin in huvecs and suppresses tumor cell-induced angiogenesis: K. Minamiguchi et al.; Int. J. Cancer 93, 307 (2001)
Expedient total synthesis of pyrrothine natural products and analogs: T. Hjelmgaard et al.; Org. Biomol. Chem. 5, 344 (2007)
Dithiolopyrrolone antibiotic formation induced by adding valeric acid to the culture broth of Saccharothrix algeriensis: R. Merrouche et al.; J. Nat. Prod. 73, 1164 (2010)

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