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Aureothricin

BVT-0345-C500 500 µg $70.00
BVT-0345-M001 1 mg $120.00
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Additional Information

Product Data
Synonyms Propionylpyrrothione; Farcinicin; N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)propionamide
Properties
Formula C9H10N2O2S2
MW 242.3
CAS 574-95-8
Source/Host Chemicals Isolated from Streptomyces thioluteus.
Purity ≥98% (HPLC)
Appearance Yellow powder.
Solubility Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key UGZYFXMSMFMTSM-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibiotic.
  • Active against Gram-positive and Gram-negative bacteria, yeast, filamentous fungi, protozoa and insects.
  • Potent bacterial and yeast RNA polymerases inhibitor.
  • Inhibitor of fungal mannan and glucan formation.
  • Similar to thiolutin.
  • Antitumor compound.

Product References

  1. The structures of thiolutin and aureothricin, antibiotics containing a unique pyrrolinonodithiole nucleus: W. D. Celmer & I. A. Solomons; J. Am. Chem. Soc. 77, 2861 (1955)
  2. Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
  3. Thiolutin, an inhibitor of huvec adhesion to vitronectin, reduces paxillin in huvecs and suppresses tumor cell-induced angiogenesis: K. Minamiguchi et al.; Int. J. Cancer 93, 307 (2001)
  4. Expedient total synthesis of pyrrothine natural products and analogs: T. Hjelmgaard et al.; Org. Biomol. Chem. 5, 344 (2007)
  5. Dithiolopyrrolone antibiotic formation induced by adding valeric acid to the culture broth of Saccharothrix algeriensis: R. Merrouche et al.; J. Nat. Prod. 73, 1164 (2010)
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