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Antibiotic PF 1052

BVT-0338-C500 500 µg $110.00
BVT-0338-M001 1 mg $190.00
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Product Data
Synonyms (E)-5-(sec-Butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione
Properties
Formula C26H39NO4
MW 429.6
CAS 147317-15-5
Source/Host Chemicals Isolated from Phoma sp.
Purity ≥98% (HPLC)
Appearance Light brown solid.
Solubility Soluble in DMSO, methanol, methylene chloride, or chloroform (all at 10mg/ml).
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key NPWKEUKXVOMELT-XTQSDGFTSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry. Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibiotic.
  • Antibacterial, antifungal and phytotoxic.
  • Anti-inflammatory agent. Described as neutrophil migration inhibitor.

Product References

  1. New antibiotic substance PF1052 and its production: T. Sasaki, et al.; Patent JP04316578A (1992)
  2. Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840.: N. Koyama et al.; J. Antibiot. 58, 338 (2005)
  3. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library: X. Wang, et al.; Dis. Model Mech. 7, 163 (2014)
  4. Loss of cftr function leads to pancreatic destruction in larval zebrafish: A. Navis, et al.; Dev. Biol. 399, 237 (2015)
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