Aphidicolin 17-acetate

More Information
Product Details
Synonyms	17-O-Acetylaphidicolin; Aphidicolin 17-monoacetate
Product Type	Chemical
Properties
Formula	C₂₂H₃₆O₅
MW	380.5
CAS	51103-57-2
Source/Host Chemicals	Isolated from Phoma sp. BS 7210.
Purity Chemicals	≥96% (HPLC, ¹H-NMR)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO or methanol.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	GAPINCSXTLCIPV-BORIEPGUSA-N
Smiles	[H][C@@]12C[C@]3([H])CC[C@@]4([H])[C@](C)(CO)[C@H](O)CC[C@]4(C)[C@]3(C1)CC[C@]2(O)COC(C)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Phytotoxin (inhibits root growth of seeding).
Specific inhibitor of eukaryotic DNA polymerase alpha and DNA synthesis (competition with dCTP).

Product References

Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983)
3-Deoxyaphidicolin and aphidicolin analogues as phytotoxin from Phoma betae: A. Ichihara, et al.; Agric. Biol. Chem. 48, 1687 (1984)
Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase alpha in vitro: S. Hiranuma, et al.; Chem. Pharm. Bull. 35, 1641 (1987)
Inhibition of DNA polymerase alpha by aphidicolin derivatives: L. Arabshahi, et al.; Nucleic Acids Res. 16, 5107 (1988)
Aphidicolin synthetic studies: a stereocontrolled end game: C. Rizzo, et al.; J. Chem. Soc. 5, 969 (1991)
Metabolites from Phoma sp. 7210, associated with Aizoon canariense: J. Dai, et al.; Nat. Prod. Comm. 5, 1175 (2010)

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