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Antibiotic L-696,474

BVT-0331-C500 500 µg $130.00
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Additional Information

Product Data
Synonyms 18-Dehydroxycytochalasin H
Properties
Formula C30H39NO4
MW 477.6
CAS 141994-72-1
Source/Host Chemicals Isolated from Hypoxylon fragiforme.
Purity ≥98% (HPLC; NMR)
Appearance White powder.
Solubility Soluble in DMSO methanol or dichlormethane.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key JVHIPYJQMFNCEK-ZPSJVCBQSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

  • Natural cytochalasin derivative.
  • Antiviral. Inhibitor of HIV-1 protease.
  • Antifungal activity.

Product References

  1. L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease: I. The producing organism and its fermentation: A.W. Dombrowski, et al.; J. Antibiot. 45, 671 (1992)
  2. L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease: II. Isolation and structure: J. Ondeyka, et al.; J. Antibiot. 45, 679 (1992)
  3. L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease: III. Biological activity: R.B. Lingham, et al.; J. Antibiot. 45, 686 (1992)
  4. Microbial transformation of L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease: T.S. Chen, et al.; J. Nat. Prod. 56, 755 (1993)
  5. An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B: A.M. Haidle & A.G. Myers; PNAS 101, 12048 (2004)
  6. Fungicidal activity of L-696,474 and cytochalasin D from the ascomycete Daldinia concentria against plant pathogenic fungi: L. Du-Qiang, et al.; Acta Phytophyl. Sinica 34, 113 (2007)
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