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BioViotica
Nebularine (high purity)
110
CHF
CHF 110.00
In stock
BVT-0304-C500500 µgCHF 110.00
BVT-0304-M0011 mgCHF 180.00
| Product Details | |
|---|---|
| Synonyms | 9-β-D-Ribofuranosyl-9H-purine; Purinosine; Ribosylpurine; NSC 65423; BRN 0091539 |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H12N4O4 |
| MW | 252.2 |
| CAS | 550-33-4 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC; NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO or methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | MRWXACSTFXYYMV-UHFFFAOYSA-N |
| Smiles | OCC1OC(C(O)C1O)N1C=NC2=CN=CN=C12 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Nucleoside analog.
- Cytotoxic. DNA, RNA and protein synthesis inhibitor.
- Shows anticancer activity.
- Anti-mycobacterial. Has tuberculostatic activity.
- Antifungal activity.
- Antiviral (anti-Herpes).
- Adenosine deaminase inhibitor.
- Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA.
Product References
- 9-β-D-ribofuranosylpurine from a Streptomycete: K. Isono & S. Suzuki; J. Antibiot. 13, 270 (1960)
- Structural requirements of nucleosides for binding by adenosine deaminase: J.G. Cory & R. Suhadolnik; Biochem. 4, 1729 (1965)
- Effects of purine riboside on nucleic acid synthesis in ascites cells: V. Bohr; Biochim. Biophys. Acta 519, 125 (1978)
- Treatment of mouse neoplasms with high doses of tubercidin: T.P. Lynch, et al.; Cancer Res. 41, 3200 (1981)
- Structure-activity relationship of ligands of human plasma adenosine deaminase 2: J.G. Niedzwicki & D.R. Abernethy; Biochem. Pharmacol. 41, 1615 (1991)
- Nebularine (9-2'-deoxy-beta-D-ribofuranosylpurine) has the template characteristics of adenine in vivo and in vitro: M.S Rahman & M.Z. Humayun; Mutat. Res. 377, 263 (1997)
- Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds: J.V. de Julian-Ortiz, et al.; J. Med. Chem. 42, 3308 (1999)
- Synthesis and stability of GNRA-loop analogs: K. Worner, et al.; Helv. Chim. Acta 82, 2094 (1999)
- Chemical constituents of the fruiting bodies of Clitocybe nebularis and their antifungal activity: Y.-S. Kim, et al.; Mycobiol. 36,110 (2008)
- Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors: I. Gillerman & B. Fischer; J. Med. Chem. 54, 107 (2011)
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