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Nebularine (high purity)

BVT-0304-C500 500 µg $90.00
BVT-0304-M001 1 mg $150.00
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Additional Information

Product Data
Synonyms 9-β-D-Ribofuranosyl-9H-purine; Purinosine; Ribosylpurine; NSC 65423; BRN 0091539
Properties
Formula C10H12N4O4
MW 252.2
CAS 550-33-4
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥98% (HPLC; NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO or methanol.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key MRWXACSTFXYYMV-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
MSDS Download Document Download

Product Description

  • Nucleoside analog.
  • Cytotoxic. DNA, RNA and protein synthesis inhibitor.
  • Shows anticancer activity.
  • Anti-mycobacterial. Has tuberculostatic activity.
  • Antifungal activity.
  • Antiviral (anti-Herpes).
  • Adenosine deaminase inhibitor.
  • Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA.

Product References

  1. 9-β-D-ribofuranosylpurine from a Streptomycete: K. Isono & S. Suzuki; J. Antibiot. 13, 270 (1960)
  2. Structural requirements of nucleosides for binding by adenosine deaminase: J.G. Cory & R. Suhadolnik; Biochem. 4, 1729 (1965)
  3. Effects of purine riboside on nucleic acid synthesis in ascites cells: V. Bohr; Biochim. Biophys. Acta 519, 125 (1978)
  4. Treatment of mouse neoplasms with high doses of tubercidin: T.P. Lynch, et al.; Cancer Res. 41, 3200 (1981)
  5. Structure-activity relationship of ligands of human plasma adenosine deaminase 2: J.G. Niedzwicki & D.R. Abernethy; Biochem. Pharmacol. 41, 1615 (1991)
  6. Nebularine (9-2'-deoxy-beta-D-ribofuranosylpurine) has the template characteristics of adenine in vivo and in vitro: M.S Rahman & M.Z. Humayun; Mutat. Res. 377, 263 (1997)
  7. Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds: J.V. de Julian-Ortiz, et al.; J. Med. Chem. 42, 3308 (1999)
  8. Synthesis and stability of GNRA-loop analogs: K. Worner, et al.; Helv. Chim. Acta 82, 2094 (1999)
  9. Chemical constituents of the fruiting bodies of Clitocybe nebularis and their antifungal activity: Y.-S. Kim, et al.; Mycobiol. 36,110 (2008)
  10. Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors: I. Gillerman & B. Fischer; J. Med. Chem. 54, 107 (2011)
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