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Pimprinine

BVT-0297-M001 1 mg $130.00
BVT-0297-M005 5 mg $390.00
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Additional Information

Product Data
Synonyms 3-(2-Methyl-5-oxazolyl)-1H-indole; Antibiotic WS-30581C; NSC80793; 5-(3-Indoyl)-2-methyloxazole
Properties
Formula C12H10N2O
MW 198.2
CAS 13640-26-1
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥98% (HPLC, NMR)
Appearance Pale yellow to beige powder.
Solubility Soluble in DMSO, methanol or acetone.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key WZJPGCHCOHYLMB-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
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Product Description

  • Indole alkaloid.
  • Monoamine oxidase inhibitor (MAOI).
  • Antiepileptic (anticonvulsant) compound.
  • Inhibitor of platelet aggregation and thromboxane A2 synthesis.
  • Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.

Product References

  1. The structure and synthesis of pimprinine: B.S. Joshi, et al.; Tetrahedron 19, 1437 (1963)
  2. Pimprinine in the treatment of hyperkinetic diseases: M.J. Narasimhan Jr. & V.G. Ganla; Hindustan Antibiot. Bull. 9, 138 (1967)
  3. Monoamine oxidase inhibitors isolated from fermented broths: T. Takeuchi, et al.; J. Antibiot. 26, 162 (1973)
  4. Studies on new antiplatelet agents, WS-30581 A and B: K. Umehara, et al.; J. Antibiot. 10, 1153 (1984)
  5. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity: S.R. Naik, et al.; J. Biotechnol. 88, 1 (2001)
  6. Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924: C. Intaraudom, et al.; Tetrahedron 67, 7593 (2011)
  7. Synthesis and fungicidal activity of novel pimprinine analogues: M.-Z. Zhang, et al.; Eur. J. Med. Chem. 53, 283 (2012)
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