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Psicofuranine

BVT-0284-M001 1 mg $80.00
BVT-0284-M005 5 mg $320.00
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Additional Information

Product Data
Synonyms Angustmycin C; U-9586; 9-β-D-Psicofuranosyl-9H-purin-6-amine
Properties
Formula C11H15N5O5
MW 297.3
Merck Index 14: 7923
CAS 1874-54-0
Source/Host Chemicals Isolated from Streptomyces sp. S 2113.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO; poorly soluble in methanol.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key BNZYRKVSCLSXSJ-IOSLPCCCSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
MSDS Download Document Download

Product Description

  • Nucleoside antibiotic.
  • Antitumor compound.
  • Xanthosine monophosphate (XMP) aminase inhibitor.
  • Antimetabolite of the purine biosynthesis.

Product References

  1. Studies on angustmycins VIII. The structure of angustmycin C: H. Yüntsen; J. Antibiot. 11A, 244 (1958)
  2. Psicofuranine I. Discovery, isolation, and properties: T.E. Eble, et al.; Antibiot. Chemother. 9, 419 (1959)
  3. Psicofuranine. VI. Antitumor and toxicopathological studies: J.S. Evans & J.E. Gray; Antibiot. Chemother. 9, 675 (1959)
  4. Mechanism of action of psicofuranine: L.J. Hanka; J. Bacteriol. 80, 30 (1960)
  5. Inhibition of parental and mutant xanthosine 5'-phosphate aminases by psicofuranine: S. Udaka & H.S. Moyed; J. Biol. Chem. 238, 2797 (1963)
  6. Formation of an adenylxanthosinemonophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine: T.T. Fukuyama; J. Biol. Chem. 241, 4745 (1966)
  7. Nucleoside antibiotics: structure, biological activity, and biosynthesis: K. Isono; J. Antibiot. 41, 1711 (1988), (Review)
  8. Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli: C.E. Rohlman & R.G. Matthews; J. Bacteriol. 172, 7200 (1990)
  9. Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase: G.A. McConkey; Exp. Parasitol. 94, 23 (2000)
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