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Manumycin B

BVT-0264-M001 1 mg $95.00
BVT-0264-M005 5 mg $285.00
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Additional Information

Product Data
Synonyms UCF1A; N98-1272A
Properties
Formula C28H34N2O7
MW 510.6
CAS 139023-58-8
Source/Host Chemicals Isolated from Streptomyces parvulus.
Purity ≥98% (HPLC)
Appearance Yellow to brown powder.
Solubility Soluble in DMSO, methanol or chloroform.
Identity Determined by 1H-NMR and UV.
Origin Manufactured by BioViotica.
InChi Key ZGICGDCGECBVTD-LOWJZYKPSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution protect from light at -20°C. Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Description

  • Antibiotic.
  • Antibacterial. Active against Gram-positive bacteria.
  • Rasfarnesyltransferase inhibitor.
  • Apoptosis (Caspase-1) inhibitor.
  • AChE inhibitor.

Product References

  1. New compounds of the manumycin group of antibiotics and a facilitated route for their structure elucidation: I. Sattler, et al.; J. Org. Chem. 58, 6583 (1993)
  2. Identification of ras farnesyltransferase inhibitors by microbial screening: M. Hara, et al.; PNAS 90, 2281 (1993)
  3. TMC-1 A, B, C and D, new antibiotics of the Manumycin group produced by Streptomyces sp.: J. Kohno, et al.; J. Antibiot. 49, 1212 (1996)
  4. EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. III. Biochemical properties of EI-1511-3, -5 and EI-1625-2: T. Tanaka, et al.; J. Antibiot. 49, 1085 (1996)
  5. The manumycin-group metabolites: I. Sattler, et al.; Nat. Prod. Rep. 15, 221 (1998) (Review)
  6. The first total synthesis of a type II manumycin antibiotic, (+)-TMC-1 A: the total syntheses of (-)-LL-C10037β and(+)-manumycin B: J.J. Cronjé Grové, et al.; Chem. Commun. 1999, 421 (1999)
  7. Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites ofan actinomycete strain: Z.-H. Zheng, et al.; J. Enzyme Inh. Med. Chem. 22, 43 (2007)
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