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Chalcomycin

BVT-0263-C500 500 µg $110.00
BVT-0263-M001 1 mg $180.00
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Additional Information

Product Data
Synonyms Aldgamycin D; NSC 150439
Properties
Formula C35H56O14
MW 700.8
CAS 20283-48-1
Source/Host Chemicals Isolated from Streptomyces bikiniensis.
Purity ≥96% (HPLC)
Appearance Beige solid.
Solubility Soluble in DMSO or acetone.
Identity Determined by 1H-NMR and UV.
Origin Manufactured by BioViotica.
InChi Key KLGADJPDTCIJLO-GQVCZQSUSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • 16-membered macrolide antibiotic. 
  • Broad spectrum antimicrobial. 
  • Antibacterial and antifungal. 
  • Protein biosynthesis inhibitor.

Product References

  1. The structure of chalcomycin: P.W.K. Woo, et al.; JACS 86, 2726 (1964)
  2. Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line: R.S. Gupta, et al.; Br. J. Cancer 58, 441 (1988)
  3. Chalcomycin: single-crystal x-ray crystallographic analysis; biosynthetic and stereochemical correlations with other polyoxo macrolide antibiotics: P.W.K. Woo & J.R. Rubin; Tetrahedron 52, 3857 (1996)
  4. Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp. B7064: R.N. Asolkar, et al.; J. Antibiot. (Tokyo) 55, 893 (2002)
  5. Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in streptomyces fradiae: S.L. Ward, et al.; Antimicrob. Agents Chemoth.  48, 4703 (2004)
  6. Aldgamycin I, an antibacterial 16-membered macrolide from the abandoned mine bacterium, Streptomyces sp. KMA-001: J.-S. Park, et al.; J. Antibiot. (Tokyo) 62, 171 (2009)
  7. Imaging secondary metabolism of Streptomyces sp. Mg1 during cellular lysis and colony degradation of competing Bacillus subtilis: S.R. Barger, et al.; Antonie Van Leeuwenhoek 102, 435 (2012)
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