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Iromycin A

BVT-0262-C500 500 µg $180.00
BVT-0262-M001 1 mg $260.00
BVT-0262-M005 5 mg $720.00
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Additional Information

Product Data
Synonyms 6-((2E,5E)-3,7-Dimethylocta-2,5-dien-1-yl)-4-hydroxy-3-methyl-5-propylpyridin-2(1H)-one
Properties
Formula C19H29NO2
MW 303.4
CAS 213137-53-2
Source/Host Chemicals Isolated from Streptomyces bottropensis (Gö-Dra17).
Purity ≥98% (HPLC)
Appearance Off-white to greenish solid.
Solubility Soluble in DMSO; fairly soluble in methanol; poorly soluble in acetone.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key HVAVEUHAOCVIPN-DTCTWCMCSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Pyridone metabolite.
  • Nitric oxide synthase (NOS) inhibitor, showing selectivity for eNOS (NOS III) versus nNOS (NOS I).
  • Thaxtomine biosynthesis inhibitor.
  • Mitochondrial electron transport chain inhibitor.

Product References

  1. Iromycins: a new family of pyridone metabolites from Streptomyces sp. II. Convergent total synthesis: H. Shojaei, et al.; J. Org. Chem. 72, 5091 (2007)
  2. The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis: F. Surup, et al; J. Org. Chem. 72, 5085 (2007)
  3. Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain: F. Surup, et al.; Bioorg. Med. Chem. 16, 1738 (2008)
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