BioViotica

Iromycin A

Name: Iromycin A
Brand: BioViotica
SKU: BVT-0262
Price: 310.00 CHF
Availability: InStock

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BVT-0262-C500500 µgCHF 215.00

BVT-0262-M0011 mgCHF 310.00

Specifications / Handling

More Information
Product Details
Synonyms	6-((2E,5E)-3,7-Dimethylocta-2,5-dien-1-yl)-4-hydroxy-3-methyl-5-propylpyridin-2(1H)-one
Product Type	Chemical
Properties
Formula	C₁₉H₂₉NO₂
MW	303.4
CAS	213137-53-2
Source/Host Chemicals	Isolated from Streptomyces bottropensis (Gö-Dra17).
Purity Chemicals	≥98% (HPLC)
Appearance	Off-white to greenish solid.
Solubility	Soluble in DMSO; fairly soluble in methanol; poorly soluble in acetone.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	HVAVEUHAOCVIPN-DTCTWCMCSA-N
Smiles	CCCC1=C(C\C=C(/C)C\C=C\C(C)C)NC(=O)C(C)=C1O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Pyridone metabolite.
Nitric oxide synthase (NOS) inhibitor, showing selectivity for eNOS (NOS III) versus nNOS (NOS I).
Thaxtomine biosynthesis inhibitor.
NADH dehydrogenase (NADH-Coenzyme Q oxidoreductase; Complex I) inhibitor. Inhibits mitochondrial respiration and oxidative phosphorylation (OXPHOS).

Product-specific References

Iromycins: a new family of pyridone metabolites from Streptomyces sp. II. Convergent total synthesis: H. Shojaei, et al.; J. Org. Chem. 72, 5091 (2007)
The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis: F. Surup, et al; J. Org. Chem. 72, 5085 (2007)
Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain: F. Surup, et al.; Bioorg. Med. Chem. 16, 1738 (2008)

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