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BioViotica
Becatecarin
205
CHF
CHF 205.00
In stock
BVT-0258-C250250 µgCHF 205.00
BVT-0258-M0011 mgCHF 590.00
| Product Details | |
|---|---|
| Synonyms | 6-N-[2-(Diethylamino)ethyl]rebeccamycin; NSC 655649; BMY-27557-14; BMS-181176; XL119 |
| Product Type | Chemical |
| Properties | |
| Formula | C33H34Cl2N4O7 |
| MW | 669.6 |
| CAS | 119673-08-4 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO or water (pH dependent). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | JSKFWUPVIZYJMR-UDOAKELVSA-N |
| Smiles | CCN(CC)CCN1C(=O)C2=C3C(NC4=C3C=CC=C4Cl)=C3N(C4OC(CO)C(OC)C(O)C4O)C4=C(C=CC=C4Cl)C3=C2C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Semisynthetic water-soluble derivative of rebeccamycin (Prod. No. BVT-0139).
- Antitumor compound.
- Topoisomerase II (Topo II) inhibitor.
- DNA intercalating agent.
Product References
- Water soluble derivatives of rebeccamycin: T. Kaneko, et al.; J. Antibiot. 43, 125 (1990)
- Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles: B.H. Long, et al.; Curr. Med. Chem. Anticancer Agents 2, 255 (2002)
- Becatecarin (Helsinn Healthcare): G.W. Rewcastle; IDrugs 8, 838 (2005) (Review)
- Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors: A.D. Ricart, et al.; Clin. Cancer Res. 11, 8728 (2005)
- A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a children`s oncology group study: A.-M. Langevin, et al.; Pediatr. Blood Cancer 50, 577 (2008)
- Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells: R. W. Robey, et al.; Cancer Chemother. Pharmacol. 64, 575 (2009)
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