BioViotica

Becatecarin

Name: Becatecarin
Brand: BioViotica
SKU: BVT-0258
Price: 590.00 CHF
Availability: InStock

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BVT-0258-C250250 µgCHF 205.00

BVT-0258-M0011 mgCHF 590.00

Specifications / Handling

More Information
Product Details
Synonyms	6-N-[2-(Diethylamino)ethyl]rebeccamycin; NSC 655649; BMY-27557-14; BMS-181176; XL119
Product Type	Chemical
Properties
Formula	C₃₃H₃₄Cl₂N₄O₇
MW	669.6
CAS	119673-08-4
Source/Host Chemicals	Semisynthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow solid.
Solubility	Soluble in DMSO or water (pH dependent).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	JSKFWUPVIZYJMR-UDOAKELVSA-N
Smiles	CCN(CC)CCN1C(=O)C2=C3C(NC4=C3C=CC=C4Cl)=C3N(C4OC(CO)C(OC)C(O)C4O)C4=C(C=CC=C4Cl)C3=C2C1=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Product-specific References

Water soluble derivatives of rebeccamycin: T. Kaneko, et al.; J. Antibiot. 43, 125 (1990)
Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles: B.H. Long, et al.; Curr. Med. Chem. Anticancer Agents 2, 255 (2002)
Becatecarin (Helsinn Healthcare): G.W. Rewcastle; IDrugs 8, 838 (2005) (Review)
Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors: A.D. Ricart, et al.; Clin. Cancer Res. 11, 8728 (2005)
A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a children`s oncology group study: A.-M. Langevin, et al.; Pediatr. Blood Cancer 50, 577 (2008)
Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells: R. W. Robey, et al.; Cancer Chemother. Pharmacol. 64, 575 (2009)

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