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Becatecarin

BVT-0258-C250 250 µg $170.00
BVT-0258-M001 1 mg $490.00
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Additional Information

Product Data
Synonyms 6-N-[2-(Diethylamino)ethyl]rebeccamycin; NSC 655649; BMY-27557-14; BMS-181176; XL119
Properties
Formula C33H34Cl2N4O7
MW 669.6
CAS 119673-08-4
Source/Host Chemicals Semisynthetic.
Purity ≥98% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO or water (pH dependent).
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key JSKFWUPVIZYJMR-UDOAKELVSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
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Product Description

  • Antibiotic.
  • Semisynthetic water-soluble derivative of rebeccamycin (Prod. No. BVT-0139).
  • Antitumor compound.
  • Topoisomerase II (Topo II) inhibitor.
  • DNA intercalating agent.

Product References

  1. Water soluble derivatives of rebeccamycin: T. Kaneko, et al.; J. Antibiot. 43, 125 (1990)
  2. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles: B.H. Long, et al.; Curr. Med. Chem. Anticancer Agents 2, 255 (2002)
  3. Becatecarin (Helsinn Healthcare): G.W. Rewcastle; IDrugs 8, 838 (2005) (Review)
  4. Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors: A.D. Ricart, et al.; Clin. Cancer Res. 11, 8728 (2005)
  5. A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a children`s oncology group study: A.-M. Langevin, et al.; Pediatr. Blood Cancer 50, 577 (2008)
  6. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells: R. W. Robey, et al.; Cancer Chemother. Pharmacol. 64, 575 (2009)
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