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BioViotica
β-Rubromycin
90
CHF
CHF 90.00
In stock
BVT-0251-M0011 mgCHF 90.00
BVT-0251-M0055 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H20O12 |
| MW | 536.4 |
| CAS | 27267-70-5 |
| Source/Host Chemicals | Isolated from Streptomyces sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Dark blue solid. |
| Solubility | Soluble in DMSO or chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | YYQMDOZKNSEHDS-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=CC2=CC3=C(O[C@@]4(CC5=C(O4)C(=O)C4=C(O)C(OC)=CC(OC)=C4C5=O)CC3)C(O)=C2C(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- HIV-1 reverse transcriptase inhibitor.
- Human telomerase inhibitor.
- Anticancer agent. Cytostatic against different tumor cell lines.
Product References
- The structure of rubromycin: H. Brockmann, et al.; THL 30, 3525 (1966)
- Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102, 126 (1969)
- Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 1709 (1970)
- Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990)
- Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000)
- Structural and biosynthetic investigations of the rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000)
- Determination of the absolute configurations of gamma-rubromycins and related spiro compounds: G. Bringmann, et. al.; Eur. J. Org. Chem. 2000, 2729 (2000)
- Rubromycins: Structurally intriguing, biologically valuable, synthetically challenging antitumour antibiotics: M. Brasholz, et al.; Eur. J. Org. Chem. 2007, 3801 (2007)
- Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid: Y. Mizushina, et al.; Mini-Rev. Med. Chem. 12, 1135 (2012)
- Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products: D.J. Atkinson & M.A. Brimble; Nat. Prod. Rep. 32, 811 (2015)
- The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets: K. Ito, et al.; Cell Rep. 39, 110721 (2022)
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