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(+)-Brefeldin A

BVT-0190-M001 1 mg $44.00
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Additional Information

Product Data
Synonyms Ascotoxin; Decumbin
Properties
Formula C16H24O4
MW 280.4
Merck Index 14: 1369
CAS 20350-15-6
Source/Host Chemicals Isolated from Eupenicillium brefeldianum.
Purity ≥97% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in acetone, DMSO, methanol or ethyl acetate (1mg/ml).
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key KQNZDYYTLMIZCT-KQPMLPITSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Protein transport from ER to Golgi inhibitor [2, 3].
  • ADP-ribosylation factor (Arf) inhibitor [6].
  • Cytotoxic [1].
  • Antibiotic [8].
  • Antiviral [8].
  • Apoptosis inducer [5].
  • Antitumor compound [9].
  • Intracellular collagen degradation inhibitor
  • Reviews [4, 7, 8].

Product References

  1. Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
  2. Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986)
  3. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988)
  4. Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review)
  5. Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996)
  6. Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF: J.B. Helms & J.E. Rothman; Nature 360,352 (1992)
  7. Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), (Review)
  8. Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective: V. Betina; Folia Microbiol. (Praha) 37, 3 (1992), (Review)
  9. The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro: D.E. Larsson, et al.; Anticancer Res. 30, 149 (2010)
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