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Deoxynojirimycin

BVT-0112-M001 1 mg $20.00
BVT-0112-M005 5 mg $70.00
BVT-0112-M025 25 mg $190.00
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Additional Information

Product Data
Synonyms 1,5-Dideoxy-1,5-imino-D-glucitol; Moranoline; DNJ
Properties
Formula C6H13NO4
MW 163.2
CAS 19130-96-2
RTECS TN4350300
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥98% (HPLC, NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO (10mg/ml) or water (10mg/ml).
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key LXBIFEVIBLOUGU-JGWLITMVSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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Product Description

  • Polyhydroxylated piperidine alkaloid.
  • α-Glucosidase I and II inhibitor.
  • Antidiabetic. Antihyperglycaemic activity.
  • Animal feedstuff additive.
  • Antiviral. Shows anti-HIV activity.

Product References

  1. Isolation and structure of an unusual cyclic amino alditol from a legume: L.E. Fellows, et al.; Chem. Comm. 22, 977 (1979)
  2. Glucosidase inhibitors from Bacilli: D.D. Schmidt, et al.; Naturwissenschaften 66, 584 (1979)
  3. Glucosiddase inhibitors: structures of deoxynojirimycin and castanospermine: A. Hempel, et al.; J. Med. Chem. 36, 4082 (1993)
  4. Polyhydroxylated alkaloids - natural occurrence and therapeutic applications: A.A. Watson, et al.; Phytochem. 56, 265 (2001)
  5. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses: J. Chang, et al.; Antiviral Research 98, 432 (2013)
  6. 1-deoxynojirimycin isolated from a bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes: S.-M. Lee, et al.; J. Microb. Biotechn. 23, 637 (2013)
  7. Novel imino sugar α-glucosidase inhibitors as antiviral compounds: J.D. Howe, et al.; Bioorg. & Med. Chem. 21, 4831 (2013)
  8. 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells: E., Shuang, et al.; Exp. Gerontol. 55, 63 (2014)
  9. 1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice: H. Do, et al.; Food Chem. Toxicol. 75, 1, (2015)
  10. 1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice: Q. Liu, et al.; Molecules 20, 21700 (2015)
  11. Iminosugars as immunomodulating agents: synthesis and biological activities of 1-deoxynojirimycin and related compounds: Q. Li & X.-S. Ye; Isr. J. Chem. 55, 336 (2015)
  12. Iminosugars: the potential of carbohydrate analogs: N. Asano; Carbohydr. Chem. 2016, 279 (2016)
  13. 1-Deoxynojirimycin alleviates liver injury and improves hepatic glucose metabolism in db/db mice: Q. Liu, et al.; Molecules 21, 279/1 (2016)
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