BioViotica

Deoxynojirimycin

Name: Deoxynojirimycin
Brand: BioViotica
SKU: BVT-0112
Price: 25.00 CHF
Availability: InStock

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BVT-0112-M0011 mgCHF 25.00

BVT-0112-M0055 mgCHF 70.00

Specifications / Handling

More Information
Product Details
Synonyms	1,5-Dideoxy-1,5-imino-D-glucitol; Moranoline; DNJ
Product Type	Chemical
Properties
Formula	C₆H₁₃NO₄
MW	163.2
CAS	19130-96-2
RTECS	TN4350300
Source/Host Chemicals	Isolated from Streptomyces sp.
Purity Chemicals	≥98% (HPLC, NMR)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO (10mg/ml) or water (10mg/ml).
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	LXBIFEVIBLOUGU-JGWLITMVSA-N
Smiles	OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Polyhydroxylated piperidine alkaloid.
α-Glucosidase I and II inhibitor.
Antidiabetic. Antihyperglycaemic activity.
Glycosylceramidase inhibitor.
Animal feedstuff additive.
Antiviral. Shows anti-HIV activity.

Product-specific References

Isolation and structure of an unusual cyclic amino alditol from a legume: L.E. Fellows, et al.; Chem. Comm. 22, 977 (1979)
Glucosidase inhibitors from Bacilli: D.D. Schmidt, et al.; Naturwissenschaften 66, 584 (1979)
Glucosiddase inhibitors: structures of deoxynojirimycin and castanospermine: A. Hempel, et al.; J. Med. Chem. 36, 4082 (1993)
Polyhydroxylated alkaloids - natural occurrence and therapeutic applications: A.A. Watson, et al.; Phytochem. 56, 265 (2001)
Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses: J. Chang, et al.; Antiviral Research 98, 432 (2013)
1-deoxynojirimycin isolated from a bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes: S.-M. Lee, et al.; J. Microb. Biotechn. 23, 637 (2013)
Novel imino sugar α-glucosidase inhibitors as antiviral compounds: J.D. Howe, et al.; Bioorg. & Med. Chem. 21, 4831 (2013)
1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells: E., Shuang, et al.; Exp. Gerontol. 55, 63 (2014)
1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice: H. Do, et al.; Food Chem. Toxicol. 75, 1, (2015)
1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice: Q. Liu, et al.; Molecules 20, 21700 (2015)
Iminosugars as immunomodulating agents: synthesis and biological activities of 1-deoxynojirimycin and related compounds: Q. Li & X.-S. Ye; Isr. J. Chem. 55, 336 (2015)
Iminosugars: the potential of carbohydrate analogs: N. Asano; Carbohydr. Chem. 2016, 279 (2016)
1-Deoxynojirimycin alleviates liver injury and improves hepatic glucose metabolism in db/db mice: Q. Liu, et al.; Molecules 21, 279/1 (2016)
1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing: K. Gao, et al.; Molecules 21, 1600 (2016) (Review)
Protective mechanism of Rice-derived Lipids and Glucosylceramide in an In Vitro Intestinal Tract Model: S. Yamashita, et al.; J. Agric. Food Chem. 69, 10206 (2021)

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