Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
BioViotica
Hormaomycin
300
CHF
CHF 300.00
In stock
BVT-0107-C500500 µgCHF 300.00
BVT-0107-M0011 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | Takaokamycin |
| Product Type | Chemical |
| Properties | |
| Formula |
C55H69N10O14Cl |
| MW | 1129.7 |
| CAS | 121548-21-8 and 92092-69-8 |
| Source/Host Chemicals | Isolated from Streptomyces griseoflavus. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO, methanol of chloroform. |
| Identity | Determined by 1H-NMR and UV. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | YOUXQVRIWHZWQN-LDXNQXMISA-N |
| Smiles | CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](C[C@@H]2C[C@H]2[N+]([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](C[C@@H]2C[C@H]2[N+]([O-])=O)NC(=O)C2=CC=C(Cl)N2O)[C@@H](C)OC(=O)[C@@H]2C[C@@H](CN2C1=O)\C=C/C)[C@H](C)C1=CC=CC=C1)[C@H](C)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic. Peptide lactone.
- Antibacterial agent (selective). Potent narrow-spectrum antibiotic against coryneform actinomycetes (MIC value 88 pM).
- Quorum sensing modulator. Shows hormonal activity.
- Inducer of morphological differentiation in actinomycetes.
- Stimulator of antibiotic production.
- Inducer of aerial mycelium formation in various actinomycetes.
- Antimalarial (in vitro).
- Rare type of natural product, regulating bacterial behavior and independently function in a defensive antibiotic role.
Product References
- Takaokamycin, a new peptide antibiotic produced by Streptomyces sp.: S. Omura, et al.; J. Antibiot. 37, 700 (1984)
- Hormaomycin, a novel peptide lactone with morphogenetic activity on Streptomyces: N. Andres, et al.; Helv. Chim. Acta 72, 426 (1989)
- Hormaomycin, a new peptide lactone antibiotic effective in inducing cytodifferentiation and antibiotic biosynthesis in some Streptomyces species: N. Andres, et al.; Z. Naturforsch. 45, 850 (1990)
- Elucidation of the structure of hormaomycin: E. Rössner, et al.; Angew. Chem. Int. Ed. Engl. 29, 64 (1990)
- In vitro antimalarial activities of the microbial metabolites: K. Otoguro, et al.; J. Antibiot. 56, 322 (2003)
- Final elucidation of the absolute configuration of the signal metabolite hormaomycin: B.D. Zlatopolskiy, et al.; Eur. J. Chem. 10, 4708 (2004)
- First total synthesis of hormaomycin, a naturally occurring depsipeptide with interesting biological activities: B.D. Zlatopolskiy, et al.; Eur. J. Chem. 10, 4718 (2004)
- The biosynthesis of 3-(trans-2-nitrocyclopropyl)alanine, a constituent of the signal metabolite hormaomycin: M. Brandl, et al.; Eur. J. Org. Chem. 2004, 123 (2004)
- Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in dmso from residual dipolar couplings in a novel dmso-compatible alignment medium: U.M. Reinscheid, et al.; ChemBioChem 7, 287 (2006)
- Synthesis and precursor-directed biosynthesis of new hormaomycin analogues: B.D. Zlatopolskiy, et al.; Eur. J. Org. Chem. 2006, 1525 (2006)
- Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite: I. Höfer, et al.; Chem. Biol. 18, 381 (2011)
Related Products
