BioViotica

Mensacarcin

Name: Mensacarcin
Brand: BioViotica
SKU: BVT-0028
Price: 155.00 CHF
Availability: InStock

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BVT-0028-M0011 mgCHF 155.00

BVT-0028-M0055 mgCHF 470.00

Specifications / Handling

More Information
Product Details
Product Type	Chemical
Properties
Formula	C₂₁H₂₄O₉
MW	420.4
CAS	808750-39-2
Source/Host Chemicals	Isolated from Streptomyces bottropensis.
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO or methanol.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	WWNXYRCJJRRWAQ-UJLZTCEPSA-N
Smiles	CO[C@H]1C2=C(OC)C=CC=C2C(=O)[C@@]23O[C@@]12[C@@H](O)[C@@](O)([C@@H](C)[C@H]3O)C(=O)[C@@H]1O[C@H]1C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Antibiotic. Cytotoxic.
Antitumor compound. Anti-melanoma drug lead compound. Effective in BRAF V600E mutation cell lines.
Potently induces apoptosis in melanoma cells. Localizes to mitochondria, affects energy metabolism in mitochondria rapidly and activates caspase-3/7-dependent apoptotic pathways.
Inhibits cell growth in a borad range of human cancer cell lines. Shows cell type specificity inducing strong cytostasis most effective in cancer types with low oxygen respiration ratios like melanomas.

Product-specific References

Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core: L.F. Tietze, et al.; Chemistry 10, 5233 (2004)
Cloning and heterologous expression of three type II pks gene clusters from Streptomyces bottropensis: X. Yan, et al.; ChemBioChem 13, 224 (2012)
Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8: S. Maier, et al.; ChemBioChem 15, 749 (2014)
Functional Characterization of Different ORFs Including Luciferase-Like Monooxygenase Genes from the Mensacarcin Gene Cluster: S. Maier, et al.; ChemBioChem 16, 1175 (2015)
The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells: B. Plitzko, et al.; J. Biol. Chem. 292, 21102 (2017)

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