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Rubiginone A2

BVT-0023-M001 1 mg $140.00
BVT-0023-M005 5 mg $460.00
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Additional Information

Product Data
Synonyms Fujianmycin B; SNA 8073A
Properties
Formula C20H16O5
MW 336.3
CAS 96695-58-8
Source/Host Chemicals Isolated from Streptomyces sp. (strain Gö N1/5).
Purity ≥98% (HPLC)
Appearance Yellow solid.
Solubility Soluble in DMSO or acetone; slightly soluble in methanol.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key MUNUJAJWLPOQBH-LZVRBXCZSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. Store solutions at -20°C in the dark.
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Product Description

  • Antibiotic.
  • Antibacterial.
  • Stereoisomer of SNA 8073B which is a prolyl endopeptidase (PEP) inhibitor.
  • Vincristine-induced cytotoxicity potentiating activity against multi-drug-resistant tumor cells.

Product References

  1. Fujianmycins A and B, new benz[a]anthraquinone antibiotics from a Streptomyces species: R.W. Rickards & J.P. Wu; J. Antibiot. 38, 513 (1985)
  2. Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity: M. Oka, et al.; J. Antibiot. 43, 967 (1990) 
  3. SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. I. Fermentation, isolation and biological properties: K. Kimura, et al.; J. Antibiot. 50, 291 (1997)
  4. Prolyl endopeptidase inhibitors derived from actinomycetes: K. Kimura, et al.; Biosci. Biotechnol. Biochem. 61, 1754 (1997)
  5. New biologically active rubiginones from Streptomyces sp.: C. Puder, et al.; J. Antibiot. 53, 329 (2000)
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