BioViotica

Antibiotic UK-1

Name: Antibiotic UK-1
Brand: BioViotica
SKU: BVT-0013
Price: 290.00 CHF
Availability: InStock

As low as CHF 95.00

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BVT-0013-C250250 µgCHF 95.00

BVT-0013-M0011 mgCHF 290.00

Specifications / Handling

More Information
Product Details
Synonyms	UK1; Methyl 2'-(2-hydroxyphenyl)-[2,4'-bibenzo[d]oxazole]-4-carboxylate; 2'-(2-Hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylic acid methyl ester
Product Type	Chemical
Properties
Formula	C₂₂H₁₄N₂O₅
MW	386.4
CAS	151271-53-3
Source/Host Chemicals	Isolated from Streptomyces sp. K17/9.
Purity Chemicals	≥98% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO, acetone or dimethylformamide.
Identity	Determined by ¹H-NMR.
Declaration	Manufactured by BioViotica.
InChi Key	NGKIDJMAXLRJRL-UHFFFAOYSA-N
Smiles	COC(=O)C1=C2N=C(OC2=CC=C1)C1=CC=CC2=C1N=C(O2)C1=CC=CC=C1O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Antibiotic.
Antifungal.
Topoisomerase II (Topo II) inhibitor. Mg²⁺- and Zn²⁺-dependent DNA binding agent.
Potent anticancer compound.

Product-specific References

UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties: M. Ueki, et al.; J. Antibiot. 46, 1089 (1993)
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation: K. Shibata, et al.; J. Antibiot. 46, 1095 (1993)
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. III. Antibacterial action of demethyl UK-1: M. Ueki and M. Taniguchi; J. Antibiot. 50, 788 (1997)
UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. IV. Antifungal action of methyl UK-1: M. Ueki, et al.; J. Antibiot. 51, 883 (1998)
The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II: M.B. Reynolds, et al.; Bioorg. Chem. 27, 326 (1999)
Evaluation of complexation of metal-mediated DNA-binding drugs to oligonucleotides via electrospray ionization mass spectrometry: M.L. Reyzer, et al.; Nucl. Acids Res. 29, E103 (2001)
Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1: D. Kumar, et al.; Bioorg. Med. Chem. 10, 3997 (2002)
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs: B.B. Wang, et al.; Bioorg. Med. Chem. Lett. 14, 3221 (2004)
Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles: O. Temiz-Arpaci, et al.; Arch. Pharm. 338, 105 (2005)
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles: S.T. Huang, et al.; Bioorg. Med. Chem. 14, 6106 (2006)

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