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Reticulol

BVT-0011-C250 250 µg $75.00
BVT-0011-M001 1 mg $160.00
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Additional Information

Product Data
Synonyms 6,8-Dihydroxy-7-methoxy-3-methyl-1H-isochromen-1-one
Properties
Formula C11H10O5
MW 222.2
CAS 26246-41-3
Source/Host Chemicals Isolated from Streptomyces sp.
Purity ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO, acetone or dimethylformamide.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key LREZRXWUEZCZRU-UHFFFAOYSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic.
  • Cyclic adenosine 3',5'-monophosphate phosphodiesterase and topoisomerase I (Topo I) inhibitor.
  • Antitumor compound.

Product References

  1. Reticulol, a new metabolic isocoumarin: L.A. Mitscher, et al.; Experientia 20, 258 (1964)
  2. Isocoumarins from Streptomyces mobaraensis: M.A.W. Eaton and D.W. Hutchinson; Tetrahedron Lett. 12, 1337 (1971)
  3. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase: Y. Furutani, et al.; J. Antibiot. 28, 558 (1975)
  4. Biosynthetic studies of reticulol, an isocoumarin, by 13C-NMR spectroscopy: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1581 (1977)
  5. Inhibition of cyclic nucleotide phosphodiesterases by reticulol: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1587 (1977)
  6. Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases: Y. Furutani, et al.; Agric. Biol. Chem. 41, 989 (1977)
  7. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma: D.S. Lim, et al.; Chemotherapy 49, 146 (2003)
  8. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma: D.S. Lim, et al.; Chemotherapy 49, 257 (2003)
  9. An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol) : A. Saeed and S. Ehsan; Chem. Heterocyc. Comp. 41, 1381 (2005)
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