γ-Rubromycin

Additional Information

Properties
Formula	C₂₆H₁₈O₁₂
MW	522.4
CAS	27267-71-6
Source/Host	Isolated from Streptomyces sp.
Purity	≥98% (HPLC)
Appearance	Red powder.
Solubility	Soluble in methylene chloride, DMSO or methanol.
Identity	Determined by ¹H-NMR.
Origin	Manufactured by BioViotica.
InChi Key	CKLKRRFSZZUFKT-UHFFFAOYSA-N
Product Type	Chemical
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light when in solution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Documents
MSDS	Download

Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 170 (1970) Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990) Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000) Rubromycins: Structurally intriguing, biologically valuable, synthetically challenging antitumour antibiotics: M. Brasholz, et al.; Eur. J. Org. Chem. 3801 (2007) Total synthesis of (+/-)-gamma-rubromycin on the basis of two aromatic Pummerer-type reactions: S. Akai, et al.; Angew. Chem. Int. Ed. 46, 7458 (2007) An efficient formal synthesis of the human telomerase inhibitor (+/-)-gamma-rubromycin: D.C. Rathwell, et al.; Angew. Chem. Int. Ed. 48, 7996 (2009)

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