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Kendomycin

BVT-0001-C100 100 µg $70.00
BVT-0001-C500 500 µg $140.00
BVT-0001-MM25 2.5 mg $420.00
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Additional Information

Product Data
Synonyms (-)-TAN 2162
Properties
Formula C29H42O6
MW 486.6
CAS 183202-73-5
Source/Host Chemicals Isolated from Streptomyces violaceoruber.
Purity ≥98% (HPLC)
Appearance Yellow powder.
Solubility Slightly soluble in methanol or DMSO.
Identity Determined by 1H-NMR.
Origin Manufactured by BioViotica.
InChi Key HKLDUJXJTQJSEJ-OLXNOMCWSA-N
Product Type Chemical
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
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Product Description

  • Antibiotic.
  • Potent endothelin receptor antagonist.
  • Anti-osteoporotic.
  • Antibacterial.
  • Cytotoxic.
  • Mediates its cytotoxic effects, at least in part, through proteasome inhibition.

Product References

  1. Structure and biosynthesis of kendomycin, a carboxylic ansa-compound from Streptomyces: H.B. Bode & A. Zeeck; J. Chem. Soc. Perkin Trans 1, 323 and 2665 (2000)
  2. Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin: Y.A. Elnakady, et al.; ChemBioChem. 8, 1261 (2007)
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