AdipoGen Life Sciences

Carbamoylcholine . chloride

Name: Carbamoylcholine . chloride
Brand: AdipoGen Life Sciences
SKU: AG-CR1-3649
Price: 95.00 CHF
Availability: InStock

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AG-CR1-3649-M100100 mgCHF 45.00

AG-CR1-3649-G0011 gCHF 95.00

Specifications / Handling

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Product Details
Synonyms	Carbachol; (2-Hydroxyethyl)trimethylammonium chloride carbamate
Product Type	Chemical
Properties
Formula	C₆H₁₅N₂O₂ . Cl
MW	147.3 . 35.4
CAS	51-83-2
RTECS	GA0875000
Purity Chemicals	≥98%
Appearance	White to yellow crystalline solid.
Solubility	Soluble in water, methanol, ethanol or DMSO.
InChi Key	AIXAANGOTKPUOY-UHFFFAOYSA-N
Smiles	NC(OCC[N+](C)(C)C)=O.[Cl-]
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Hygroscopic. Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Acetylcholine analog that activates acetylcholine receptors (AChR).
Non-selective agonist of nicotinic (nAChR) and muscarinic (mAChR) receptors that is resistant to the action of cholinesterases.
Used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility and neuronal signaling.
Shown to inhibit apoptotic death of cultured neurons.

Product-specific References

Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons: G.M. Yan, et al.; Mol. Pharmacol. 47, 248 (1995)
Carbamoylcholine homologs: Novel and potent agonists at neuronal nicotinic acetylcholine receptors: A.A. Jensen, et al.; Mol. Pharmacol. 64, 865 (2003)
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells: Y. Xiao & K.J. Kellar; J. Pharmacol. Exp. Ther. 310, 98 (2004)
Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line: A.L. Lin, et al.; Am. J. Physiol. Cell Physiol. 294, C1454 (2008)
K+ACh channel activation with carbachol increases atrial ANP release: D.Y. Xu, et al.; Life Sci. 82, 1083 (2008)
IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages: D. Mori, et al.; J. Pharmacol. Sci. 125, 394 (2014)

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